Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas
Abstract Background Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months.Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic properties, has been implicated in GBM growth.We hypothesized that Sema3A directly inhibits brain tumor stem cell (BTSC) prolifer